Structure of PDB 4fw3 Chain A

Receptor sequence
>4fw3A (length=302) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
SNAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPV
VEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSA
SEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFV
PFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDI
EYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLY
LLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYM
RP
3D structure
PDB4fw3 Crystal Structure of the LpxC
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H78 H237 D241 H81 H240 D244
BS02 L52 A M62 E77 T190 F191 G209 H237 D241 H264 M65 E80 T193 F194 G212 H240 D244 H267 BindingDB: Kd=58.6nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0009245 lipid A biosynthetic process
GO:0019637 organophosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fw3, PDBe:4fw3, PDBj:4fw3
PDBsum4fw3
PubMed
UniProtP47205|LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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