Structure of PDB 4ful Chain A

Receptor sequence

>4fulA (length=832) Species: 9606 (Homo sapiens)

EESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPK
LYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAI
LQSFFTKMDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTP
PDPALDEVRKECDRKFRVKIRGIDIPVLLTVFVEANIQHGQQVLCQRRTS
PKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCKVRLLYYVNLLLIDH
RFLLRRGEYVLHMWQISFNADKLTSATNPDKENSMSISILLDNYCHPVRA
EMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSS
VKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAV
QKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFL
FWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKV
TLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGA
LAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLIL
QILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQST
VGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIG
DRHNDNIMITETGNLFHIDFGHIRVPFVLTPDFLFVMGTSKTSPHFQKFQ
DICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKN
EEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL

3D structure

• PDB: 4ful Identification of pyrimidine derivatives as hSMG-1 inhibitors.
• Chain: A
• Resolution: 2.47 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.1.137: phosphatidylinositol 3-kinase.
  2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
  2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0VU	A	M804 W812 K833 Y867 I879 E880 I881 V882 A885 K890 M953 I963	M559 W567 K588 Y622 I634 E635 I636 V637 A640 K645 M708 I718

Gene Ontology

Molecular Function

• GO:0016301 kinase activity

Biological Process

• GO:0046854 phosphatidylinositol phosphate biosynthetic process

External links

• PDB: RCSB:4ful, PDBe:4ful, PDBj:4ful
• PDBsum: 4ful
• PubMed: 23021994
• UniProt: P48736|PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)