Structure of PDB 4ftw Chain A

Receptor sequence
>4ftwA (length=220) Species: 272943 (Cereibacter sphaeroides 2.4.1) [Search protein sequence]
IMTRKLTFGRRGAAPGEATSLVVFLHGYGADGADLLGLAEPLAPHLPGTA
FVAPDAPEPCRACGFGFQWFPIPWLDGSSETAAAEGMAAAARDLDAFHDE
RLAEEGLPPEALALVGFSQGTMMALHVAPRRAEEIAGIVGFSGRLLAPER
LAEEARSKPPVLLVHGDADPVVPFADMSLAGEALAEAGFTTYGHVMKGTG
HGIAPDGLSVALAFLKERLP
3D structure
PDB4ftw Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y75 S165 L193 R203 D216 H248
Catalytic site (residue number reindexed from 1) Y28 S118 L146 R156 D169 H201
Enzyme Commision number 3.1.1.1: carboxylesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIN A Y75 G76 C110 F112 Y28 G29 C63 F65
BS02 3CM A L122 H248 G249 L75 H201 G202
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4ftw, PDBe:4ftw, PDBj:4ftw
PDBsum4ftw
PubMed22987200
UniProtQ3J2V1

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