Structure of PDB 4ft4 Chain A

Receptor sequence
>4ft4A (length=688) Species: 4577 (Zea mays) [Search protein sequence]
HEPEFIGSPVAADEARSNWPKRYELKARCHYRSAKVDNVVYCLGDDVYVK
AGENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGHK
HDPRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYYD
MSYSVAYSTFANITRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWAV
DFNSFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYVEFVVEKLV
GICYGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEGH
KRKILPLPGDVDVICGGPPCQGISGFNRYRNRDEPLKDEKNKQMVTFMDI
VAYLKPKYVLMENVVDILKFADGYLGKYALSCLVAMKYQARLGMMVAGCY
GLPQFRMRVFLWGALSSMVLPKYPLPTYDVVVRGGAPNAFSQCMVAYDET
QKPSLKKALLLGDAISDLPKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKD
MLDWSFGEGAGPDEGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGV
RVGANNIVEWDPEIERVKLSSGKPLVPDYAMSFIKGKSLKPFGRLWWDET
VPTVVTRAEPHNQVIIHPTQARVLTIRENARLQGFPDYYRLFGPIKEKYI
QVGNAVAVPVARALGYCLGQAYLGESEGSDPLYQLPPS
3D structure
PDB4ft4 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C517 E559 R603 R605
Catalytic site (residue number reindexed from 1) C320 E362 R406 R408
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K195 Y203 W224 N258 N260 K50 Y58 W79 N113 N115
BS02 SAH A Y347 G349 G352 D375 F376 K397 A398 Q540 A852 V853 Y173 G175 G178 D201 F202 K223 A224 Q343 A655 V656
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4ft4, PDBe:4ft4, PDBj:4ft4
PDBsum4ft4
PubMed23021223
UniProtQ9AXT8|CMT1_MAIZE DNA (cytosine-5)-methyltransferase 1 (Gene Name=MET2A)

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