Structure of PDB 4fo8 Chain A

Receptor sequence
>4fo8A (length=259) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
TVTIKTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVN
EQKAIPAPLNYKGFPKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIK
DGYHGDTSKMFLVGKTPEWADRLCQITQECMYKGISVVRPGAHLGDIGEI
IQKHAEKNGFSVVREYCGHGIGKVFHEEPQVLHYGRAGTGIELKEGMIFT
IEPMINQGRPETRLLGDGWTAITKDRKLSAQWEHTVLVTADGYEILTLRN
DETFPRTSA
3D structure
PDB4fo8 Methionine excision captured by the structures of a methionine aminopeptidase
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D96 D107 H170 H177 E203 E234
Catalytic site (residue number reindexed from 1) D95 D106 H169 H176 E202 E233
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D107 H170 T201 E203 E234 D106 H169 T200 E202 E233
BS02 MN A D96 D107 E234 D95 D106 E233
BS03 MN A N74 V76 S230 N73 V75 S229
BS04 MET A F65 D96 D107 F176 E203 W220 E234 F64 D95 D106 F175 E202 W219 E233
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4fo8, PDBe:4fo8, PDBj:4fo8
PDBsum4fo8
PubMed
UniProtQ9HXY1

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