Structure of PDB 4fn8 Chain A

Receptor sequence
>4fn8A (length=230) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SMSDPVSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRDDVGAL
VITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLLSYPKPVVMA
CTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYAALEIMKLRL
TRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEEAAREFAGLN
QHAHAATKLRSRADALTAIRAGIDGIAAEF
3D structure
PDB4fn8 Crystal structure and mechanism of the prokaryotic enoyl CoA isomerase (ECI)
ChainA
Resolution1.831 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F62 M107 F110 N129 E130 I137
Catalytic site (residue number reindexed from 1) F63 M108 F111 N130 E131 I138
Enzyme Commision number 4.2.1.17: enoyl-CoA hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAA A K22 V23 R56 G60 G61 F62 D63 L64 L67 H103 A106 M107 N129 E130 M135 K23 V24 R57 G61 G62 F63 D64 L65 L68 H104 A107 M108 N130 E131 M136
Gene Ontology
Biological Process
GO:0006635 fatty acid beta-oxidation

View graph for
Biological Process
External links
PDB RCSB:4fn8, PDBe:4fn8, PDBj:4fn8
PDBsum4fn8
PubMed
UniProtI6Y8B5

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