Structure of PDB 4fmo Chain A

Receptor sequence
>4fmoA (length=264) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
RVNVNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDL
KLFLIDYGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFD
ELNDDASKEKIISKIWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLL
LKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVPKV
DTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKDVVE
IANLPDLYKVFERC
3D structure
PDB4fmo Structure of the MutL alpha C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
ChainA
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N510 L511 T512 M626 E629 Y630 E682 C685 N5 L6 T7 M121 E124 Y125 E177 C180
BS02 MG A D531 H553 D26 H48
Gene Ontology
Molecular Function
GO:0016887 ATP hydrolysis activity
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair
Cellular Component
GO:0032300 mismatch repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fmo, PDBe:4fmo, PDBj:4fmo
PDBsum4fmo
PubMed23435383
UniProtP38920|MLH1_YEAST DNA mismatch repair protein MLH1 (Gene Name=MLH1)

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