Structure of PDB 4fl6 Chain A

Receptor sequence
>4fl6A (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
AWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSV
YCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLH
PPKGYKEEEFNWQTYLKTCKAQAAPKSLFEVIPSGFRVGMKLEAVDKKNP
SFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRT
LITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVD
KRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSK
TGHPLQPPL
3D structure
PDB4fl6 Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UWN A D381 N384 F387 C389 F405 W408 Y412 D146 N149 F152 C154 F170 W173 Y177 BindingDB: Kd=120nM,IC50=49nM
BS02 UWN A D274 H277 F298 Y301 Y305 H330 D409 E410 D44 H47 F68 Y71 Y75 H100 D174 E175 BindingDB: Kd=120nM,IC50=49nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4fl6, PDBe:4fl6, PDBj:4fl6
PDBsum4fl6
PubMed23292653
UniProtQ96JM7|LMBL3_HUMAN Lethal(3)malignant brain tumor-like protein 3 (Gene Name=L3MBTL3)

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