Structure of PDB 4fjz Chain A

Receptor sequence
>4fjzA (length=822) Species: 9606 (Homo sapiens) [Search protein sequence]
SQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLY
AMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQ
SFDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALD
EVRKEDCDRKFRVKIRGIDIPVLDLTVFVEANIQHGQQVLCQRRTSPKPF
TEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKVQLLYYVNLLLIDHRFL
LRRGEYVLHMWQISSFNADKLTSATNPDKENSMSISILLDNIALPKAEMP
NQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKW
GQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKL
ESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWF
LRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLD
IKSLSADVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKC
KVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIM
ESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGAFKD
EVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMI
TETGNLFHIDFGHKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKA
YLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKK
YFLDQIEVCRDKGWTVQFNWFL
3D structure
PDB4fjz Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4FJ A M804 P810 W812 K833 E880 I881 V882 T887 K890 I963 D964 M553 P559 W561 K582 E629 I630 V631 T636 K639 I709 D710 PDBbind-CN: -logKd/Ki=6.29,Ki=509nM
BindingDB: Ki=509nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fjz, PDBe:4fjz, PDBj:4fjz
PDBsum4fjz
PubMed22876881
UniProtP48736|PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)

[Back to BioLiP]