Structure of PDB 4fjv Chain A

Receptor sequence
>4fjvA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
SETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNC
FYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNA
FYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFR
HFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDT
ALNHHVFPEAATPSVYLLYKTSHYNILYAAD
3D structure
PDB4fjv The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.
ChainA
Resolution2.047 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NEH A G49 C51 G48 C50
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0006508 proteolysis
GO:0016579 protein deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:2000780 negative regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:4fjv, PDBe:4fjv, PDBj:4fjv
PDBsum4fjv
PubMed25590432
UniProtQ96DC9|OTUB2_HUMAN Ubiquitin thioesterase OTUB2 (Gene Name=OTUB2)

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