Structure of PDB 4fiy Chain A

Receptor sequence
>4fiyA (length=628) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MSELAASLLSRVILPRPGEPLDVRKLYLEESTTNARRAHAPTRTSLQIGA
ESEVSFATYFNAFPASYWRRWTTCKSVVLRVQVTGAGRVDVYRTKATGAR
IFVEGHDFTGTEDQPAAVETEVVLQPFEDGGWVWFDITTDTAVTLHSGGW
YATSPAPGTANIAVGIPTFNRPADCVNALRELTADPLVDQVIGAVIVPDQ
GERKVRDHPDFPAAAARLGSRLSIHDQPNLGGSGGYSRVMYEALKNTDCQ
QILFMDDDIRLEPDSILRVLAMHRFAKAPMLVGGQMLNLQEPSHLHIMGE
VVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSKLLHRRIDVDYNGWWTC
MIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWS
DKDDAIDWQAYFHLRNRLVVAAMHWDGPKAQVIGLVRSHLKATLKHLACL
EYSTVAIQNKAIDDFLAGPEHIFSILESALPQVHRIRKSYPDAVVLPAAS
ELPPPLHKNKAMKPPVNPLVIGYRLARGIMHNLTAANPQHHRRPEFNVPT
QDARWFLLCTVDGATVTTADGCGVVYRQRDRAKMFALLWQSLRRQRQLLK
RFEEMRRIYRDALPTLSSKQKWETALLP
3D structure
PDB4fiy Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan.
ChainA
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.1.288: galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho- decaprenol beta-1,5/1,6-galactofuranosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A F169 R171 N229 G231 G232 F367 F169 R171 N229 G231 G232 F367
BS02 MN A D256 D258 H396 D256 D258 H396
Gene Ontology
Molecular Function
GO:0008921 lipopolysaccharide-1,6-galactosyltransferase activity
GO:0016740 transferase activity
GO:0016757 glycosyltransferase activity
GO:0035250 UDP-galactosyltransferase activity
GO:0035496 lipopolysaccharide-1,5-galactosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0044038 cell wall macromolecule biosynthetic process
GO:0045227 capsule polysaccharide biosynthetic process
GO:0052573 UDP-D-galactose metabolic process
GO:0070592 cell wall polysaccharide biosynthetic process
GO:0071555 cell wall organization
GO:0071769 mycolate cell wall layer assembly
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4fiy, PDBe:4fiy, PDBj:4fiy
PDBsum4fiy
PubMed22707726
UniProtO53585|GLFT2_MYCTU Galactofuranosyltransferase GlfT2 (Gene Name=glfT2)

[Back to BioLiP]