Structure of PDB 4fiv Chain A

Receptor sequence
>4fivA (length=113) Species: 11673 (Feline immunodeficiency virus) [Search protein sequence]
VGTTTTLEKRPEILIFVNGYPIKFLLDTGADITILNRRDFQVKNSIENGR
QNMIGVGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLIQPLLG
RDNMIKFNIRLVM
3D structure
PDB4fiv Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LP1 A R13 D30 G32 A33 D34 M56 I57 R10 D27 G29 A30 D31 M53 I54 MOAD: Ki=300nM
PDBbind-CN: -logKd/Ki=6.52,Ki=300nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4fiv, PDBe:4fiv, PDBj:4fiv
PDBsum4fiv
PubMed9827997
UniProtQ66972

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