Structure of PDB 4fif Chain A

Receptor sequence
>4fifA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
PQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGK
LVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVM
EFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS
ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPE
VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL
KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR
3D structure
PDB4fif Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D145 K147 D149 S150 D163 K172 T183
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S331 R359 T404 D444 F461 L475 G477 Y480 W481 F516 S36 R64 T109 D149 F166 L180 G182 Y185 W186 F221
BS02 ANP A E329 G330 S331 T332 V335 K350 M395 F397 L398 L447 D458 G460 F461 E34 G35 S36 T37 V40 K55 M100 F102 L103 L152 D163 G165 F166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fif, PDBe:4fif, PDBj:4fif
PDBsum4fif
PubMed22988085
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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