Structure of PDB 4fic Chain A

Receptor sequence
>4ficA (length=251) Species: 9031 (Gallus gallus) [Search protein sequence]
LAKDAWEIPRESLRLEVKLGQGEVWMGTWNGTTRVAIKTLKPLQEAQVMK
KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVD
MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGFPIKWTAPE
AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP
CPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGEN
L
3D structure
PDB4fic De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D121 R123 A125 N126 D139 F142
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0UL A A293 Y340 M341 G344 L393 A36 Y75 M76 G79 L128 MOAD: ic50=20uM
PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
BindingDB: IC50=2.0e+4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fic, PDBe:4fic, PDBj:4fic
PDBsum4fic
PubMed23534475
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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