Structure of PDB 4fhk Chain A

Receptor sequence
>4fhkA (length=819) Species: 9606 (Homo sapiens) [Search protein sequence]
EESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPK
LYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAI
LQSFFTKMDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTP
PDPALDEVRKECDRKFRVKIRGIDIPVLDLTVFVEANIQHGQQVLCQRRT
SPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCVQLLYYVNLLLIDH
RFLLRRGEYVLHMWQISSFNADKLTSATNPDKENSMSISILLDNEMPNQL
RKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQ
EIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESL
EDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRS
EIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKS
LKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVM
ASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESI
WETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNAFKDEV
LNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITE
TGNLFHIDFGHIKERVPFVLTPDFLFVMGTSKTSPHFQKFQDICVKAYLA
LRHHTNLLIILFSMMLMTGMSKEDIEYIRDALTVGKNEEDAKKYFLDQIE
VCRDKGWTVQFNWFLHLVL
3D structure
PDB4fhk Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0U0 A M804 W812 I831 K833 Y867 I879 V882 A885 M953 I963 D964 M550 W558 I577 K579 Y613 I625 V628 A631 M697 I707 D708
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fhk, PDBe:4fhk, PDBj:4fhk
PDBsum4fhk
PubMed22765895
UniProtP48736|PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)

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