Structure of PDB 4fg9 Chain A

Receptor sequence
>4fg9A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEENEIA
VLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDA
SRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFPGYVA
PEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYE
FDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNI
HQSVSEQIKKNFAKSKWKQAFNATAVVR
3D structure
PDB4fg9 Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 N146 D162
Catalytic site (residue number reindexed from 1) D123 K125 N128 D144
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G27 S32 V34 A47 K49 V98 E102 K143 E145 N146 L148 D162 G18 S23 V25 A38 K40 V80 E84 K125 E127 N128 L130 D144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fg9, PDBe:4fg9, PDBj:4fg9
PDBsum4fg9
PubMed23028635
UniProtQ14012|KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (Gene Name=CAMK1)

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