Structure of PDB 4fg7 Chain A

Receptor sequence
>4fg7A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
RWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIASMENEI
AVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD
ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK
MEDPGTPGYVAPEVLAQKSKAVDCWSIGVIAYILLCGYPPFYDENDAKLF
EQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA
3D structure
PDB4fg7 Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 N146 D162 T181
Catalytic site (residue number reindexed from 1) D124 K126 N129 D145 T156
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G29 F31 S32 V34 A47 K49 V98 D162 G21 F23 S24 V26 A39 K41 V81 D145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fg7, PDBe:4fg7, PDBj:4fg7
PDBsum4fg7
PubMed23028635
UniProtQ14012|KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (Gene Name=CAMK1)

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