Structure of PDB 4ff8 Chain A

Receptor sequence
>4ff8A (length=169) Species: 10090 (Mus musculus) [Search protein sequence]
KEFDHPHVAKLVILPFMKHGDLHAFLLASRIPLQTLVRFMVDIACGMEYL
SSRNFIHRDLAARNCMLAEDMTVCVAVKWLALESLADNLYTVHSDVWAFG
VTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMVYDLMYQCWSA
DPKQRPSFTCLRMELENIL
3D structure
PDB4ff8 Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D645 A647 R649 N650
Catalytic site (residue number reindexed from 1) D59 A61 R63 N64
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 14S A A571 L593 P594 F595 M596 K597 G599 D600 M652 A662 A9 L14 P15 F16 M17 K18 G20 D21 M66 A76 MOAD: ic50=0.4uM
PDBbind-CN: -logKd/Ki=6.40,IC50=0.40uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ff8, PDBe:4ff8, PDBj:4ff8
PDBsum4ff8
PubMed23312472
UniProtP55144|TYRO3_MOUSE Tyrosine-protein kinase receptor TYRO3 (Gene Name=Tyro3)

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