Structure of PDB 4feq Chain A

Receptor sequence
>4feqA (length=224) Species: 10090 (Mus musculus) [Search protein sequence]
EQQFTLGRMLGKGSVREAQLKDGSFVKVAVKMLFLREAACMKEFDHPHVA
KLVGVSPMVILPFMKHGDLHAFLLASRIPLQTLVRFMVDIACGMEYLSSR
NFIHRDLAARNCMLAEDMTVCVADFGVKWLALESLADNLYTVHSDVWAFG
VTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCW
SADPKQRPSFTCLRMELENILGHL
3D structure
PDB4feq Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D645 A647 R649 N650 D663
Catalytic site (residue number reindexed from 1) D106 A108 R110 N111 D124
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0T8 A L514 A538 L593 F595 M596 K597 H598 M652 D663 L10 A29 L61 F63 M64 K65 H66 M113 D124 MOAD: ic50=1.1uM
PDBbind-CN: -logKd/Ki=5.96,IC50=1.1uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4feq, PDBe:4feq, PDBj:4feq
PDBsum4feq
PubMed23312472
UniProtP55144|TYRO3_MOUSE Tyrosine-protein kinase receptor TYRO3 (Gene Name=Tyro3)

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