Structure of PDB 4fef Chain A

Receptor sequence
>4fefA (length=315) Species: 5323 (Pleurotus eryngii) [Search protein sequence]
ATCDDGRTTANAACCILFPILDDIQENLFDGAQCGEEVHESLRLTFHDAI
GFSPTLGGGGADGSIIAFDTIETNFPANAGIDEIVSAQKPFVAKHNISAG
DFIQFAGAVGVSNCPGGVRIPFFLGRPDAVAASPDHLVPEGFDSVDSILA
RMGDAGFSPVEVVWLLASHSIAAADKVDPSIPGTPFDSTPEVFDSQFFIE
TQLKGRLFPGTADNKGEAQSPLQGEIRLQSDHLLARDPQTACEWQSMVNN
QPKIQNRFAATMSKMALLGQDKTKLIDCSDVIPTPPALVGAAHLPAGFSL
SDVEQACAATPFPAL
3D structure
PDB4fef Two Oxidation Sites for Low Redox Potential Substrates: A DIRECTED MUTAGENESIS, KINETIC, AND CRYSTALLOGRAPHIC STUDY ON PLEUROTUS ERYNGII VERSATILE PEROXIDASE.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R43 H47 H169 F186 D231
Catalytic site (residue number reindexed from 1) R43 H47 H169 F186 D231
Enzyme Commision number 1.11.1.16: versatile peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D48 G60 D62 S64 D48 G60 D62 S64
BS02 CA A S170 D187 T189 V192 D194 S170 D187 T189 V192 D194
BS03 HEM A E36 H39 E40 L42 R43 F46 E140 L166 S168 H169 A172 A173 A174 D175 K176 V177 F186 L228 E36 H39 E40 L42 R43 F46 E140 L166 S168 H169 A172 A173 A174 D175 K176 V177 F186 L228
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0016689 manganese peroxidase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0052750 reactive-black-5:hydrogen-peroxide oxidoreductase activity
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006979 response to oxidative stress
GO:0034599 cellular response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0046274 lignin catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:4fef, PDBe:4fef, PDBj:4fef
PDBsum4fef
PubMed23071108
UniProtO94753|VPL2_PLEER Versatile peroxidase VPL2 (Gene Name=vpl2)

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