Structure of PDB 4fea Chain A

Receptor sequence
>4feaA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
TYQYNMNFEKLGKCIIINNKDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHVTPIKDLTAHFRGDRCKTLLEKPKLF
FIQACPVEADFLFAYSTVRGSWFVQALCSILEEHGKDLEIMQILTRVNDR
VARHIPCVVSMLTKELYFSQ
3D structure
PDB4fea A class of allosteric caspase inhibitors identified by high-throughput screening.
ChainA
Resolution3.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H144 C186
Catalytic site (residue number reindexed from 1) H74 C105
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0TE A V292 M294 V159 M161 PDBbind-CN: -logKd/Ki=6.47,Ki=0.34uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4fea, PDBe:4fea, PDBj:4fea
PDBsum4fea
PubMed22795132
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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