Structure of PDB 4fdj Chain A

Receptor sequence
>4fdjA (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]
PQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANP
LCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPEL
LKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPN
IPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFF
LYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHV
ADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWP
GHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRL
MDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGV
TTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQE
ALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLW
3D structure
PDB4fdj The Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A.
ChainA
Resolution2.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D39 D40 C79 R83 K140 H142 P163 H236 D288 N289 K310
Catalytic site (residue number reindexed from 1) D12 D13 C52 R56 K113 H115 P136 H209 D261 N262 K283
Enzyme Commision number 3.1.6.4: N-acetylgalactosamine-6-sulfatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D39 D40 X79 D288 N289 D12 D13 X52 D261 N262
Gene Ontology
Molecular Function
GO:0003943 N-acetylgalactosamine-4-sulfatase activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0016787 hydrolase activity
GO:0043890 N-acetylgalactosamine-6-sulfatase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:4fdj, PDBe:4fdj, PDBj:4fdj
PDBsum4fdj
PubMed22940367
UniProtP34059|GALNS_HUMAN N-acetylgalactosamine-6-sulfatase (Gene Name=GALNS)

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