Structure of PDB 4fda Chain A

Receptor sequence
>4fdaA (length=243) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MHYLPVAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERRGQLQSG
LSYQRQCAIAIDFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNK
WSNNERRYYVNLLINCAGLTQESLSVRTTASQIQDIMNVNFMSPVTMTNI
CIKYMMKSQRRWPELSGQARPTIVNISSILHSGKMKVPGTSVYSASKAAL
SRFTEVLAAEMEPRNIRCFTISPGLGTSAPAEIAEEVWSLYSR
3D structure
PDB4fda Crystal structure of Saccharomyces cerevisiae 3-oxoacyl-[acyl-carrier-protein] reductase complexed with NADPH
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G15
Catalytic site (residue number reindexed from 1) G15
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G11 T13 R14 S36 S40 I65 F67 A121 G122 T124 Q125 V143 T195 Y198 G11 T13 R14 S36 S40 I61 F63 A117 G118 T120 Q121 V139 T190 Y193
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0048038 quinone binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0009060 aerobic respiration
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Cellular Component
External links
PDB RCSB:4fda, PDBe:4fda, PDBj:4fda
PDBsum4fda
PubMed
UniProtP35731|FABG_YEAST 3-oxoacyl-[acyl-carrier-protein] reductase (Gene Name=OAR1)

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