Structure of PDB 4fc7 Chain A

Receptor sequence
>4fc7A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
PPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGC
HTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKE
FGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFF
RDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRV
NSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLA
SPLASYVTGAVLVADGGAWLTFPN
3D structure
PDB4fc7 Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids
ChainA
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G39 A165 Q175 H177 A178 K182
Catalytic site (residue number reindexed from 1) G36 A162 Q172 H174 A175 K179
Enzyme Commision number 1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing].
Interaction with ligand
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0009062 fatty acid catabolic process
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Cellular Component
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4fc7, PDBe:4fc7, PDBj:4fc7
PDBsum4fc7
PubMed22745130
UniProtQ9NUI1|DECR2_HUMAN Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (Gene Name=DECR2)

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