Structure of PDB 4fb3 Chain A

Receptor sequence
>4fb3A (length=115) [Search protein sequence]
SDFPSSLTGYLSHAIYSNKTFPAFLVYSTKEKCKQLYDTIGKFRPEFKCL
VHYEEGGMLFFLTMTKHRVSAVKNYCSKLCSVSFLMCKAVTKPMECYQVV
TAAPFQLITENKPGL
3D structure
PDB4fb3 Polyomavirus large T antigen binds symmetrical repeats at the viral origin in an asymmetrical manner.
ChainA
Resolution3.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A N307 T309 K355 H356 R357 A360 N18 T20 K66 H67 R68 A71 PDBbind-CN: Kd=38nM
BS02 dna A S301 H302 A303 I304 Y305 S306 N307 K308 S12 H13 A14 I15 Y16 S17 N18 K19 PDBbind-CN: Kd=38nM
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
Biological Process
GO:0006260 DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4fb3, PDBe:4fb3, PDBj:4fb3
PDBsum4fb3
PubMed24109229
UniProtP0DOJ4|LT_POVBG Large T antigen

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