Structure of PDB 4fai Chain A

Receptor sequence
>4faiA (length=302) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
ELVDIPKISYNPSELSEPRFLEYSNLSDKLHLREAIDKILIPRVVGTTNH
SIVREYIVQSLRDLDWDVEVNSFHDHAPIKGKLHFHNIIATLNPNAERYL
VLSCHYDSKYMPGVEFLGATDSAVPCAMLLNLAQVLQEQLKPLKKSKLSL
MLLFFDGEEAFEEWGPKDSIYGARHLAKKWHHEGKLDRIDMLVLLDLLGA
PDPAFYSFFENTESWYMRIQSVETRLAKLQLRYFQSQAMRSSFIEDDHIP
FLRRNVPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYL
LA
3D structure
PDB4fai Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D153 E191 H318 D121 E159 H271
BS02 PBD A D153 E190 E191 W196 D228 E292 F313 W317 H318 D121 E158 E159 W164 D196 E245 F266 W270 H271 PDBbind-CN: -logKd/Ki=6.99,Ki=101.3nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region
GO:0005739 mitochondrion

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Molecular Function
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Cellular Component
External links
PDB RCSB:4fai, PDBe:4fai, PDBj:4fai
PDBsum4fai
PubMed22897232
UniProtQ86PD7|QPCT2_DROME Glutaminyl-peptide cyclotransferase (Gene Name=isoQC)

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