Structure of PDB 4fa7 Chain A

Receptor sequence

>4fa7A (length=546) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

YPEKKATLYFLVLGFLALIVGSLFGPFQALNYGNVDAYPLLKRLLPFVQS
YYQGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGLMWLSWWMAF
IGLVVAALPLLANEATVLYTFYPPLKGHWAFYLGASVFVLSTWVSIYIVL
DLWRRWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEFVLFLLPWSFG
LVEGVDPLVARTLFWWTGHPIVYFWLLPAYAIIYTILPKQAGGKLVSDPM
ARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSVLTLFVAVPSLMTAF
TVAASLEFAGRLRGGRGLFGWIRALPWDNPAFVAPVLGLLGFIPGGAGGI
VNASFTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLLPNLTGKPIS
DAQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNVPRRAYIAQVPDAYPHAA
VPMVFNVLAGIVLLVALLLFIYGLFSVLLSRERKPELAEAPLPFAEVISE
DRRLVLAMDRIGFWFAVAAILVVLAYGPTLVQLFGHLNPVPGWRLW

3D structure

PDB

4fa7 ?

Chain

Resolution

2.5 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H72 P101 Y133 S155 T156 H233 I235 Y237 Y248 H282 H283 S309 G331 H384 F385 H386 R449 R450
Catalytic site (residue number reindexed from 1)	H58 P87 Y119 S141 T142 H219 I221 Y223 Y234 H268 H269 S295 G317 H370 F371 H372 R435 R436
Enzyme Commision number	7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU	A	H233 H282 H283	H219 H268 H269
BS02	HEM	A	G39 Q42 A43 Y46 Y65 L69 H72 N76 L132 Y133 F385 H386 A390 T394 W428 M432 M435 R450 L477	G25 Q28 A29 Y32 Y51 L55 H58 N62 L118 Y119 F371 H372 A376 T380 W414 M418 M421 R436 L463
BS03	HAS	A	Y133 W229 V236 Y237 W239 H282 H283 S309 A313 L353 L354 F356 G360 G363 N366 A367 D372 H376 V381 H384 F385 Q388 V389 R449	Y119 W215 V222 Y223 W225 H268 H269 S295 A299 L339 L340 F342 G346 G349 N352 A353 D358 H362 V367 H370 F371 Q374 V375 R435

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4fa7, PDBe:4fa7, PDBj:4fa7
PDBsum	4fa7
PubMed
UniProt	Q5SJ79\|COX1_THET8 Cytochrome c oxidase subunit 1 (Gene Name=cbaA)

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