Structure of PDB 4f9v Chain A

Receptor sequence
>4f9vA (length=307) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
IGSQWRDDEVHFNRTLDSILVPRVVGSRGHQQVREYLVQSLNGLGFQTEV
DEFKQRVPVFGELTFANVVGTINPQAQNFLALAAHYDSKYFPNDPGFVGA
TDSAVPAAILLNTAKTLGAYLQKEFRNRSDVGLMLIFFDGEEAFKEWTDA
DSVYGSKHLAAKLASKRSGSQAQLAPRNIDRIEVLVLLDLIGARNPKFSS
FYENTDGLHSSLVQIEKSLRTAGQLEGNNNMFLSRVSGGLVDDDHRPFLD
ENVPVLHLVATPFPDVWHTPRDNAANLHWPSIRNFNRVFRNFVYQYLKRH
TSPVNLR
3D structure
PDB4f9v Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D131 E171 H297 D102 E142 H268
BS02 PBD A D131 E170 E171 W176 D218 D271 F292 W296 H297 D102 E141 E142 W147 D189 D242 F263 W267 H268 PDBbind-CN: -logKd/Ki=6.03,Ki=944nM
BS03 PBD A V88 F89 V59 F60 PDBbind-CN: -logKd/Ki=6.03,Ki=944nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:4f9v, PDBe:4f9v, PDBj:4f9v
PDBsum4f9v
PubMed22897232
UniProtQ9VRQ9|QPCT1_DROME Glutaminyl-peptide cyclotransferase (Gene Name=QC)

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