Structure of PDB 4f9u Chain A

Receptor sequence
>4f9uA (length=298) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
QWRDDEVHFNRTLDSILVPRVVGSRGHQQVREYLVQSLNGLGFQTEVDEF
KQRVPVFGELTFANVVGTINPQAQNFLALACHYDSKYFPNDPGFVGATDS
AVPCAILLNTAKTLGAYLQKEFRNRSDVGLMLIFFDGEEAFKEWTDADSV
YGSKHLAAKLASKRSPRNIDRIEVLVLLDLIGARNPKFSSFYENTDGLHS
SLVQIEKSLRTAGQLEGNNNMFLSRVSGGLVDDDHRPFLDENVPVLHLVA
TPFPDVWHTPRDNAANLHWPSIRNFNRVFRNFVYQYLKRHTSPVNLRF
3D structure
PDB4f9u Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
ChainA
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D131 E171 H297 D99 E139 H258
BS02 PBD A D131 E170 E171 W176 D218 V270 D271 F292 H297 D99 E138 E139 W144 D179 V231 D232 F253 H258 MOAD: Ki=3139nM
PDBbind-CN: -logKd/Ki=6.03,Ki=944nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4f9u, PDBe:4f9u, PDBj:4f9u
PDBsum4f9u
PubMed22897232
UniProtQ9VRQ9|QPCT1_DROME Glutaminyl-peptide cyclotransferase (Gene Name=QC)

[Back to BioLiP]