Structure of PDB 4f9m Chain A

Receptor sequence
>4f9mA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKDLY
3D structure
PDB4f9m Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A K301 L311 Q314 V315 L318 K319 E471 K85 L95 Q98 V99 L102 K103 E255
BS02 FCM A K263 G284 C285 F287 R288 S289 L330 M334 I341 M348 M364 K367 K57 G68 C69 F71 R72 S73 L114 M118 I125 M132 M148 K151
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4f9m, PDBe:4f9m, PDBj:4f9m
PDBsum4f9m
PubMed22727448
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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