Structure of PDB 4f9g Chain A

Receptor sequence
>4f9gA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLRGAVSQRLYILLPL
DCGVPDNLSMADPNIRFLDKLPQYSNSIYELLENGQRAGTCVLEYATPLQ
TLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPNNCRLIAYQEPSF
SLSQEVLRHLRQEEKEEVTV
3D structure
PDB4f9g Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E A Y167 T263 P264 Y14 T97 P98 Manual survey: Km=2.4+-0.5mM (22705373)
PDBbind-CN: -logKd/Ki=5.62,Kd=2.4uM
BindingDB: EC50=4500nM,Kd=1210nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4f9g, PDBe:4f9g, PDBj:4f9g
PDBsum4f9g
PubMed22705373
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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