Structure of PDB 4f9c Chain A

Receptor sequence
>4f9cA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
KKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK
HLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHE
SFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLK
KYALVDFGLAQGTHDTKIELLKFVRAGTPGFRAPEVLTKCPNQTTAIDMW
SAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSIL
CSKEVPAQDLRKLCERLRWNEVPDEAYDLLDKLLDLNPASRITAEEALLH
PFFKDM
3D structure
PDB4f9c Crystal structure of human CDC7 kinase in complex with its activator DBF4.
ChainA
Resolution2.08 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D137 K139 N142 D156 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SX A V72 A88 K90 M118 M134 Y136 L137 N182 L184 V195 D196 V32 A48 K50 M78 M94 Y96 L97 N142 L144 V155 D156 BindingDB: IC50=3.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f9c, PDBe:4f9c, PDBj:4f9c
PDBsum4f9c
PubMed23064647
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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