Structure of PDB 4f9b Chain A

Receptor sequence
>4f9bA (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIA
LKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLE
HESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR
LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQVAPRAGTPGFRAPEVLTK
CPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETI
QAAKTFGKSILCSKEVPAQDLRKLCERLRGWNEVPDEAYDLLDKLLDLNP
ASRITAEEALLHPFFKDM
3D structure
PDB4f9b Crystal structure of human CDC7 kinase in complex with its activator DBF4.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D139 K141 N144 D158 T189
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SY A A88 K90 Y136 L137 L184 V195 D196 A50 K52 Y98 L99 L146 V157 D158 BindingDB: IC50=10nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4f9b, PDBe:4f9b, PDBj:4f9b
PDBsum4f9b
PubMed23064647
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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