Structure of PDB 4f9a Chain A

Receptor sequence
>4f9aA (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIA
LKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLE
HESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR
LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQRAGTPGFRAPEVLTKCPN
QTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAA
KTFGKSILCSKEVPAQDLRKLCERLRGWNEVPDEAYDLLDKLLDLNPASR
ITAEEALLHPFFKDM
3D structure
PDB4f9a Crystal structure of human CDC7 kinase in complex with its activator DBF4.
ChainA
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D139 K141 N144 D158 T186
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A S70 V72 A88 K90 M118 Y136 L137 H139 L184 D196 S32 V34 A50 K52 M80 Y98 L99 H101 L146 D158
BS02 MG A N182 D196 N144 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f9a, PDBe:4f9a, PDBj:4f9a
PDBsum4f9a
PubMed23064647
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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