Structure of PDB 4f7s Chain A

Receptor sequence
>4f7sA (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYA
LKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYA
EHDLWHIIKFHRASKQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPAN
ILVMGEGPERGRVKIADMGFARLFNSPLKPTFWYRAPELLLGARHYTKAI
DIWAIGCIFAELLTSEPIFHCRTSNPYHHDQLDRIFNVMGFPADKDWEDI
KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP
IKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB4f7s Structure-kinetic relationship study of CDK8/CycC specific compounds.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 N181 T196
Catalytic site (residue number reindexed from 1) D145 K147 N150 D167 N175 T181
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SW A A50 I79 F97 Y99 A100 D103 H106 A155 L158 R356 A50 I79 F97 Y99 A100 D103 H106 A149 L152 R336
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f7s, PDBe:4f7s, PDBj:4f7s
PDBsum4f7s
PubMed23630251
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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