Structure of PDB 4f7j Chain A

Receptor sequence
>4f7jA (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYA
LKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYA
EHDLWHIIKFHRQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILV
MGEGPERGRVKIADMGFVTFWYRAPELLLGARHYTKAIDIWAIGCIFAEL
LTSEPIFHCRQNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDF
RRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDP
YFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB4f7j Structure-kinetic relationship study of CDK8/CycC specific compounds.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 T196
Catalytic site (residue number reindexed from 1) D142 K144 N147 D164 T169
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SU A Y32 K52 S62 R65 E66 A172 D173 Y32 K52 S62 R65 E66 A163 D164 PDBbind-CN: -logKd/Ki=5.24,Kd=5.82uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4f7j, PDBe:4f7j, PDBj:4f7j
PDBsum4f7j
PubMed23630251
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

[Back to BioLiP]