Structure of PDB 4f6x Chain A

Receptor sequence
>4f6xA (length=281) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDS
IDDIQFLNQIKEDIQSIEKYPYEYHHFQSDRRIMMALQHVAQHKNIAFQS
FYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQT
YDVARRLGESLQLINILRDVGEDFENERIYFSKQRLKQYEVDIAEVYQNG
VNNHYIDLWEYYAAIAEKDFRDVMDQIKVFSIEAQPIIELAARIYIEILD
EVRQANYTLHERVFVEKRKKAKLFHEINSKY
3D structure
PDB4f6x HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.96: 4,4'-diapophytoene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZYL A H18 F22 A134 V137 L164 Q165 N168 F233 Y248 H18 F22 A131 V134 L161 Q162 N165 F230 Y245 MOAD: ic50=45.3uM
PDBbind-CN: -logKd/Ki=5.09,IC50=8.2uM
BindingDB: IC50=45300nM,Ki=450nM
BS02 MG A N168 D172 N165 D169
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004311 farnesyltranstransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016767 geranylgeranyl-diphosphate geranylgeranyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0016117 carotenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4f6x, PDBe:4f6x, PDBj:4f6x
PDBsum4f6x
PubMed22662288
UniProtA9JQL9|CRTM_STAAU 4,4'-diapophytoene synthase (Gene Name=crtM)

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