Structure of PDB 4f6w Chain A

Receptor sequence
>4f6wA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYA
LKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYA
EHDLWHIIKFHRASKVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPA
NILVMGEGPERGRVKIADMGFATFWYRAPELLLGARHYTKAIDIWAIGCI
FAELLTSEPIFHCRQNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTL
MKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQA
MQDPYFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB4f6w Structure-kinetic relationship study of CDK8/CycC specific compounds.
ChainA
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 T196
Catalytic site (residue number reindexed from 1) D146 K148 N151 D168 T173
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SS A V27 Y32 S62 E66 F97 W105 A172 D173 M174 R356 V27 Y32 S62 E66 F97 W105 A167 D168 M169 R327 PDBbind-CN: -logKd/Ki=7.52,Kd=0.03uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f6w, PDBe:4f6w, PDBj:4f6w
PDBsum4f6w
PubMed23630251
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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