Structure of PDB 4f6u Chain A

Receptor sequence
>4f6uA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD
YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD
YAEHDLWHIIKFHRASKVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLK
PANILVMGEGPERGRVKIADMGFVVTFWYRAPELLLGARHYTKAIDIWAI
GCIFAELLTSEPIFHCRQENPYHHDQLDRIFNVMGFPADKDWEDIKKMPE
HSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT
SEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB4f6u Structure-kinetic relationship study of CDK8/CycC specific compounds.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 T196
Catalytic site (residue number reindexed from 1) D148 K150 N153 D170 T176
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SR A Y32 A50 S62 R65 E66 I79 F97 A100 I171 A172 D173 Y34 A52 S64 R67 E68 I81 F99 A102 I168 A169 D170 PDBbind-CN: -logKd/Ki=6.15,Kd=0.70uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f6u, PDBe:4f6u, PDBj:4f6u
PDBsum4f6u
PubMed23630251
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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