Structure of PDB 4f6n Chain A

Receptor sequence

>4f6nA (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]

DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKV
FPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGD
SKLYRLHPCRSLQIRQYAYL

3D structure

PDB

4f6n Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso.

Chain

Resolution

2.8 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R501 Y503 V504 S508 R511 E535 Y536 Q563 Y597 A598	R21 Y23 V24 S28 R31 E55 Y56 Q83 Y117 A118	PDBbind-CN: Kd=190pM
BS02	dna	A	R511 K520 E535 T538 R549 Y550 Y562 S578 Y584 L586 R595 Y597	R31 K40 E55 T58 R69 Y70 Y82 S98 Y104 L106 R115 Y117	PDBbind-CN: Kd=190pM
BS03	ZN	A	C496 C499 H512 H516	C16 C19 H32 H36
BS04	ZN	A	C524 H540 H544	C44 H60 H64
BS05	ZN	A	C552 C555 H568 H573	C72 C75 H88 H93

External links

PDB	RCSB:4f6n, PDBe:4f6n, PDBj:4f6n
PDBsum	4f6n
PubMed	22949637
UniProt	Q86T24\|KAISO_HUMAN Transcriptional regulator Kaiso (Gene Name=ZBTB33)