Structure of PDB 4f5y Chain A

Receptor sequence
>4f5yA (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
GNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYI
LLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLEN
GQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB4f5y Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
ChainA
Resolution2.396 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D205 E316 D55 E166 Manual survey: Kd=3.7uM (22728660)
BS02 C2E A S162 Y167 R238 V239 T263 S12 Y17 R88 V89 T113 Manual survey: Kd=3.7uM (22728660)
PDBbind-CN: -logKd/Ki=5.43,Kd=3.70uM
BindingDB: EC50=4500nM,Kd=1210nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4f5y, PDBe:4f5y, PDBj:4f5y
PDBsum4f5y
PubMed22728660
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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