Structure of PDB 4f4y Chain A

Receptor sequence

>4f4yA (length=343) Species: 273057,330779 [Search protein sequence]

MIVIFVDFDYFFAQVEEVLNPQYKGKPLVVCVYSGRTKTSGAVATANYEA
RKLGVKAGMPIIKAMQIAPSAIYVPMRKPIYEAFSNRIMNLLNKHADKIE
VASIDEAYLDVTNKVEGNFENGIELARKIKQEILEKEKITVTVGVAPNKI
LAKIIADKSKPNGLGVIRPTEVQDFLNELDIDEIPGIGSVLARRLNELGI
QKLRDILSKNYNELEKITGKAKALYLLKLAQDEYNEPIRTRVRKSIGRYL
TLPYNTRDVKVILPYLKKAINEAYNKVNGIPMRITVIAIMEDLDILSKGK
KFKHGISIDNAYKVAEDLLRELLVRDKRRNVRRIGVKLDNIII

3D structure

PDB

4f4y Y-family polymerase conformation is a major determinant of fidelity and translesion specificity.

Chain

Resolution

2.338 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S103 D105 E106 G186 G188 Y225 R241 S297 K298 K301 K303 R325	S103 D105 E106 G186 G188 Y225 R241 S297 K298 K301 K303 R325
BS02	dna	A	V32 S34 G41 A42 P60 I62 K63 K78 K220 A221 R243 K244 S245 I246 G247 R248 Y249 T251 L293 R332 R333	V32 S34 G41 A42 P60 I62 K63 K78 K220 A221 R243 K244 S245 I246 G247 R248 Y249 T251 L293 R332 R333
BS03	DCP	A	Y10 F12 A44 T45 R51 D105	Y10 F12 A44 T45 R51 D105
BS04	CA	A	D7 F8 D105	D7 F8 D105
BS05	CA	A	D7 D105 E106	D7 D105 E106

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4f4y, PDBe:4f4y, PDBj:4f4y
PDBsum	4f4y
PubMed	23245850
UniProt	Q4JB80\|DPO4_SULAC DNA polymerase IV (Gene Name=dbh); Q97W02\|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)

[Back to BioLiP]