Structure of PDB 4f4w Chain A

Receptor sequence

>4f4wA (length=342) Species: 273057,330779 [Search protein sequence]

MIVIFVDFDYFFAQVEEVLNPQYKGKPLVVCVYSGRTKTSGAVATANYEA
RKLGVKAGMPIIKAMQIAPSAIYVPMRKPIYEAFSNRIMNLLNKHADKIE
VASIDEAYLDVTNKVEGNFENGIELARKIKQEILEKEKITVTVGVAPNKI
LAKIIADKSKPNGLGVIRPTEVQDFLNELDIDEIPGIGSVLARRLNELGI
QKLRDILSKNYNELEKITGKAKALYLLKLAQDEYNEPIRTRVRKSIGRIV
TMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRG
RTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI

3D structure

PDB

4f4w Y-family polymerase conformation is a major determinant of fidelity and translesion specificity.

Chain

Resolution

1.898 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S298 R299 G300 R301 T302 K340	S298 R299 G300 R301 T302 K340
BS02	dna	A	V32 S34 G41 A42 G219 A221 R243 K244 S245 G247 R248 I249 T251 L294 R332 R333 R337	V32 S34 G41 A42 G219 A221 R243 K244 S245 G247 R248 I249 T251 L294 R332 R333 R337
BS03	dna	A	P79 A83 F84 R87	P79 A83 F84 R87
BS04	dna	A	V18 L19 R87	V18 L19 R87
BS05	DCP	A	D9 Y10 F11 F12 A44 T45 Y48 R51 D105 K160	D9 Y10 F11 F12 A44 T45 Y48 R51 D105 K160
BS06	CA	A	D7 F8 D105	D7 F8 D105
BS07	CA	A	D7 D105 E106	D7 D105 E106

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:4f4w, PDBe:4f4w, PDBj:4f4w
PDBsum	4f4w
PubMed	23245850
UniProt	Q4JB80\|DPO4_SULAC DNA polymerase IV (Gene Name=dbh); Q97W02\|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)

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