Structure of PDB 4f4u Chain A

Receptor sequence
>4f4uA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
TARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFGYWRKWQAQDLA
TPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVV
VITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSG
KGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVD
RELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFR
FHFQGPCGTTLPEALA
3D structure
PDB4f4u The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 N141 D143 H158
Catalytic site (residue number reindexed from 1) P36 T37 F38 N105 D107 H122
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y102 R105 I142 H158 V221 W222 F223 G224 E225 N226 L227 V253 V254 Y255 P256 Y66 R69 I106 H122 V185 W186 F187 G188 E189 N190 L191 V217 V218 Y219 P220
BS02 ZN A C166 C169 C207 C212 C130 C133 C171 C176
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4f4u, PDBe:4f4u, PDBj:4f4u
PDBsum4f4u
PubMed22767592
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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