Structure of PDB 4f4p Chain A

Receptor sequence
>4f4pA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
LDRKLLTLEDKELGSGNFGTVKKGYVKTVAVKILKPALKDELLAEANVMQ
QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV
HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY
YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG
MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR
LRNYYYDVVNEG
3D structure
PDB4f4p Highly potent aminopyridines as Syk kinase inhibitors.
ChainA
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512 K533
Catalytic site (residue number reindexed from 1) D119 A121 R123 N124 D137 K158
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SB A L377 V385 A400 M448 A451 G454 P455 N499 L501 S511 L13 V21 A30 M73 A76 G79 P80 N124 L126 S136 MOAD: ic50=0.6nM
PDBbind-CN: -logKd/Ki=9.22,IC50=0.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f4p, PDBe:4f4p, PDBj:4f4p
PDBsum4f4p
PubMed22877633
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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