Structure of PDB 4f4c Chain A

Receptor sequence
>4f4cA (length=1250) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
NGSLRQSLRTLDSFSLAPEDVLKTAIKTVEDYEGDNIDSNGEIKITRDEV
VNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFI
NEQIVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIT
VTCYLYVAEQMNNRLRREFVKSILRQEISWFDTNHSGTLATKLFDNLERV
KEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAI
AKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVE
EAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDML
TTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAG
RKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCG
KSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNC
TIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLS
GGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTT
IIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFT
DAVDSAAEGERIGKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFI
GMSTATIGGFIYPTYSVFFTSFMNVFAGNPADFLSQGHFWALMFLVLAAA
QGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKIS
TRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAIL
PIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDT
FYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALII
TDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLR
KISKIDSLSLAGEKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQ
TLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIA
IVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEG
FETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVV
QEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEK
3D structure
PDB4f4c Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.2: ABC-type xenobiotic transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0SA A E22 Q913 L990 S1029 G1032 E19 Q857 L934 S973 G976
BS02 0SA A Q913 Y914 R916 G1032 T1035 Q857 Y858 R860 G976 T979
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0010038 response to metal ion
GO:0042908 xenobiotic transport
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0055085 transmembrane transport
GO:0093002 response to nematicide
Cellular Component
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4f4c, PDBe:4f4c, PDBj:4f4c
PDBsum4f4c
PubMed23000902
UniProtP34712|PGP1_CAEEL Multidrug resistance protein pgp-1 (Gene Name=pgp-1)

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