Structure of PDB 4f3i Chain A

Receptor sequence
>4f3iA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4f3i Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0S6 A W81 P82 L92 L94 N140 I146 M149 W40 P41 L51 L53 N99 I105 M108 MOAD: Kd=36.1nM
PDBbind-CN: -logKd/Ki=7.44,Kd=36.1nM
BindingDB: Ki=17nM,IC50=18.2nM
External links
PDB RCSB:4f3i, PDBe:4f3i, PDBj:4f3i
PDBsum4f3i
PubMed22645123
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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