Structure of PDB 4f1y Chain A

Receptor sequence
>4f1yA (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKL
SIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA
VYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGEC
3D structure
PDB4f1y The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CNI A Y61 P89 L90 T91 R96 T174 E193 Y58 P86 L87 T88 R93 T171 E190 MOAD: Kd=0.96uM
BS02 ZN A K45 H46 K42 H43
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4f1y, PDBe:4f1y, PDBj:4f1y
PDBsum4f1y
PubMed22512472
UniProtP19492|GRIA3_RAT Glutamate receptor 3 (Gene Name=Gria3)

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