Structure of PDB 4f1o Chain A

Receptor sequence
>4f1oA (length=276) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
RLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGET
EMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMEFVPCGDLYHR
LLDKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLD
ENAPVCAKVADFGTSQQSVHSVSGLLGNFQWMAPETIGAEEESYTEKADT
YSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRN
VIELCWSGDPKKRPHFSYIVKELSEL
3D structure
PDB4f1o Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1154 R1156 P1158 N1159 D1177 N1194
Catalytic site (residue number reindexed from 1) D138 R140 P142 N143 D161 N178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A I1032 K1034 V1040 A1053 F1107 V1108 R1156 F1161 D1177 I16 K18 V24 A37 F91 V92 R140 F145 D161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f1o, PDBe:4f1o, PDBj:4f1o
PDBsum4f1o
PubMed22689969
UniProtQ6XHB2|ROCO4_DICDI Probable serine/threonine-protein kinase roco4 (Gene Name=roco4)

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