Structure of PDB 4f1l Chain A

Receptor sequence
>4f1lA (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
QNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKK
KTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTY
FAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQ
NPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB4f1l Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0RY A H1601 G1602 N1624 Y1633 F1634 A1635 Y1640 S1641 Y1646 H68 G69 N91 Y100 F101 A102 Y107 S108 Y113 PDBbind-CN: -logKd/Ki=5.12,Kd=7.6uM
BindingDB: IC50=>20000nM,Kd=7600nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4f1l, PDBe:4f1l, PDBj:4f1l
PDBsum4f1l
PubMed22823910
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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